SCHEMBL4623378

SCHEMBL4623378

CCCCCCN([C@@H](CCC(=O)O)C(N)=O)C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 7/20 0.41
PPARG P37231 7/20 0.41
PPARD Q03181 7/20 0.41
PPARA Q07869 7/20 0.41
HDAC11 Q96DB2 5/20 0.41
TSHR P16473 4/20 0.41
PTPN1 P18031 3/20 0.41
ALDH1A1 P00352 2/20 0.41
TLR2 O60603 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
FABP4 P15090 2/20 0.41
FFAR1 O14842 2/20 0.41
FFAR4 Q5NUL3 2/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
SLC22A8 Q8TCC7 1/20 0.41
MEN1 O00255 1/20 0.41
ESR1 P03372 1/20 0.41
ALOX15 P16050 1/20 0.41
PDE4A P27815 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28078461 0.79 AKR1B1 (0.42) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL8431792 0.75 EPHX2 (0.43) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL28184751 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL3249203 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL3249208 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL29978075 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL15047640 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL29977697 0.72 NOD1 (0.56) GPR84PPARGPPARDPPARAHDAC11
SCHEMBL11785410 0.72 GABRP (0.41) TSHRALDH1A1TDP1FFAR1FFAR4
Hydrochloric Acid SCHEMBL5034548 0.71 NOD1 (0.55) GPR84PPARGPPARDPPARAHDAC11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1902014-A2 GLUTAMATE AGGRECANASE INHIBITORS Wyeth (US) 2008-03-26 EP disclosed
WO-2007008994-A2 GLUTAMATE AGGRECANASE INHIBITORS WYETH (US) 2007-01-18 WO disclosed