SCHEMBL4623552

SCHEMBL4623552

CCc1nc2c([nH]1)c(=O)[nH]c(=O)n2C1CCCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.46
ADORA2B P29275 3/20 0.46
ALDH1A1 P00352 9/20 0.46
LMNA P02545 3/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TSHR P16473 2/20 0.44
GAA P10253 1/20 0.44
BRCA1 P38398 1/20 0.44
ADORA1 P30542 2/20 0.44
HCAR1 Q9BXC0 1/20 0.41
NPSR1 Q6W5P4 2/20 0.41
ALOX15 P16050 1/20 0.41
KDM4E B2RXH2 1/20 0.40
MAPK1 P28482 1/20 0.40
POLB P06746 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
TP53 P04637 1/20 0.39
PKM P14618 1/20 0.38
MTOR P42345 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11016180 0.93 ADORA1 (0.41) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL11019634 0.82 POLB (0.46) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL10981520 0.80 ADORA1 (0.42) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL11021594 0.79 ADORA2A (0.53) ADORA2AADORA2BADORA1MTOR
SCHEMBL7615743 0.79 HCAR1 (0.41) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL22560002 0.76 PIK3CD (0.45) ADORA2BALDH1A1MEN1KMT2ATSHR
SCHEMBL18036532 0.76 EEF2K (0.43) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL7623849 0.76 SIRT2 (0.44) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL639181 0.74 EEF2K (0.42) ADORA2AADORA2BALDH1A1LMNAMEN1
SCHEMBL538418 0.72 ADORA2A (0.54) ADORA2AADORA2BALDH1A1LMNAADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904020-A2 NEW SLIMMING COSMETIC COMPOSITIONS Sederma S.A.S. (FR) 2008-04-02 EP disclosed
WO-2007010478-A2 SLIMMING COSMETIC COMPOSITIONS SEDERMA (FR) 2007-01-25 WO disclosed
EP-1497444-A4 METHODS FOR INCREASING POLYPEPTIDE PRODUCTION IMMUNEX CORP (US) 2006-08-30 EP disclosed
EP-1497444-A2 METHODS FOR INCREASING POLYPEPTIDE PRODUCTION Immunex Corporation (US) 2005-01-19 EP disclosed
WO-2003083066-A2 METHODS FOR INCREASING POLYPEPTIDE PRODUCTION IMMUNEX CORPORATION (US) 2003-10-09 WO disclosed