Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.57 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623675 | 0.85 | AQP1 (0.57) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6047979 | 0.83 | SSTR2 (0.44) | AQP1SSTR2SSTR4SIRT2 | |
| SCHEMBL5203385 | 0.78 | AQP1 (0.69) | AQP1SSTR2SSTR4HTR2AHTR2C | |
| SCHEMBL4225768 | 0.78 | AQP1 (0.69) | AQP1SSTR2SSTR4HTR2AHTR2C | |
| SCHEMBL4220558 | 0.78 | AQP1 (0.72) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4225668 | 0.76 | AQP1 (0.67) | AQP1SSTR2SSTR4HTR2ASIRT2 | |
| SCHEMBL13911343 | 0.76 | AQP1 (0.76) | AQP1SIRT2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL8254836 | 0.76 | AQP1 (0.72) | AQP1SSTR2SSTR4HTR2AHTR2C | |
| SCHEMBL4220568 | 0.76 | AQP1 (0.72) | AQP1SSTR2SSTR4HTR2AHTR2C | |
| SCHEMBL4596640 | 0.76 | AQP1 (0.72) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |