Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624257 | 1.00 | HPGD (0.52) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4623462 | 1.00 | HPGD (0.52) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4625167 | 1.00 | HPGD (0.52) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4625013 | 1.00 | HPGD (0.52) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4625450 | 0.91 | HPGD (0.51) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4624758 | 0.91 | HPGD (0.53) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4623459 | 0.91 | HPGD (0.51) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4624888 | 0.89 | HPGD (0.49) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL4625575 | 0.87 | HPGD (0.52) | HPGDHTTGAARAB9AALDH1A1 | |
| SCHEMBL20703871 | 0.84 | SMN1; SMN2 (0.57) | HPGDHTTGAARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020458-B1 | OPTICALLY ACTIVE 1,4-BENZODIOXINE-2-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | NISSHIN PHARMA INC (JP) | 2008-05-07 | — | — | EP | disclosed |
| US-6509482-B2 | Chemical intermediates for synthesis of optical isomers useful as prophylactic and therapeutic agents for diabetes and hyperglycemia | NISSHIN PHARMA INC. (JP) | 2003-01-21 | — | — | US | disclosed |
| US-20020028957-A1 | Optically active 1,4-benzodioxin-2-carboxylic acid derivatives and process for producing the same | NISSHIN PHARMA INC. (JP) | 2002-03-07 | — | — | US | disclosed |
| US-6329533-B2 | CHEMICAL INTERMEDIATE FOR ANTIDIABETIC DRUG | NISSHIN PHARMA INC. (JP) | 2001-12-11 | — | — | US | disclosed |
| US-20010018529-A1 | Optically active 1,4-benzodioxin-2-carboxylic acid derivatives and process for producing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2001-08-30 | — | — | US | disclosed |
| US-6222050-B1 | AS CHEMICAL INTERMEDIATES USEFUL FOR SYNTHESIS OF (RRR)-OPTICAL ISOMERS OF 1,4-BENZODIOXIN-2-CARBOXYLIC ACID DERIVATIVES WHICH ARE USEFUL AS PROPHYLACTIC AND THERAPEUTIC AGENT FOR DIABETES, HYPERGLYCEMIA | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-1020458-A1 | OPTICALLY ACTIVE 1,4-BENZODIOXINE-2-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Nisshin Flour Milling Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028957-A1 | Optically active 1,4-benzodioxin-2-carboxylic acid derivatives and process for producing the same | GPR119, CBR1, ADH1C | HPGD 607/4885HTT 4488/4885GAA 2251/4885 |
| US-20010018529-A1 | Optically active 1,4-benzodioxin-2-carboxylic acid derivatives and process for producing the same | CBR1, GPR119, ADH1C | HPGD 594/4885HTT 4503/4885GAA 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.