SCHEMBL4624144

SCHEMBL4624144

COc1ccc(C=CC=O)c(OC)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 14/20 0.75
CYP1A1 P04798 13/20 0.75
CYP1B1 Q16678 13/20 0.75
ALDH1A1 P00352 3/20 0.70
NFE2L2 Q16236 2/20 0.66
MAPT P10636 3/20 0.65
MEN1 O00255 2/20 0.65
KMT2A Q03164 2/20 0.65
CYP3A4 P08684 2/20 0.62
CYP2C19 P33261 2/20 0.62
CYP2E1 P05181 1/20 0.62
CYP2C8 P10632 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2A6 P11509 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP4B1 P13584 1/20 0.62
CYP2B6 P20813 1/20 0.62
CYP3A5 P20815 1/20 0.62
CYP2A7 P20853 1/20 0.62
CYP3A7 P24462 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL714242 1.00 CYP1A2 (0.75) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL29575647 1.00 CYP1A2 (0.75) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL1426024 0.93 CYP1A2 (0.70) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL29915985 0.93 CYP1A2 (0.70) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL1426026 0.93 CYP1A2 (0.70) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL24017227 0.88 CYP1A2 (0.58) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL5877571 0.87 CYP1A1 (0.69) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL2121298 0.87 CYP1A1 (0.69) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL26924044 0.86 CYP1A2 (0.84) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2
SCHEMBL25706432 0.86 CYP1A2 (1.00) CYP1A2CYP1A1CYP1B1ALDH1A1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376441-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT UNIV YONSEI IACF (KR) 2025-12-11 US disclosed
US-20220226340-A1 CASEIN KINASE 1 INHIBITORS FOR USE IN THE TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION SUCH AS MUSCULAR DYSTROPHY AND CANCER Facio Intellectual Property B.V. (NL) 2022-07-21 US disclosed
EP-3982955-A1 CASEIN KINASE 1 INHIBITORS FOR USE IN THE TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION SUCH AS MUSCULAR DYSTROPHY AND CANCER Facio Intellectual Property B.V. (NL) 2022-04-20 EP disclosed
US-20210289794-A1 COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE FLAGSHIP PIONEERING INNOVATIONS V, INC. 2021-09-23 US disclosed
WO-2020249717-A1 CASEIN KINASE 1 INHIBITORS FOR USE IN THE TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION SUCH AS MUSCULAR DYSTROPHY AND CANCER Facio Intellectual Property B.V. (NL) 2020-12-17 WO disclosed
US-20200190024-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2020-06-18 US disclosed
CN-110279680-A A kind of medical composition and its use 有联生技股份有限公司 2019-09-27 CN disclosed
CN-106220507-A Compound with (1E,6E) -1, 7-bis- (3, 4-dimethoxyphenyl) -4, 4-disubstituted hepta-1, 6-diene-3, 5-dione structural framework and application thereof 有联生技股份有限公司 2016-12-14 CN disclosed
CN-104755076-A Compounds having (1E,6E) -1, 7-bis- (3, 4-dimethoxyphenyl) -4, 4-disubstituted hepta-1, 6-diene-3, 5-dione structural skeleton, their biological activity and use thereof ANDROSCIENCE CORP 2015-07-01 CN disclosed
CN-100502846-C 3,4,5,-substituted benzyl ethylene derivatives and their preparation and use ZHEJIANG HAIZHENG PHARMACEUTIC (CN) 2009-06-24 CN disclosed
EP-1070726-B1 ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS AJINOMOTO KK (JP) 2008-02-20 EP disclosed
US-6566557-B2 Oxidation of a phenylpropane compound COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2003-05-20 US disclosed
EP-1045842-B1 METHODS OF USE AND COMPOSITIONS FOR BENZYLIDENE- AND CINNAMYLIDENE-ANABASEINES UNIV FLORIDA (US) 2003-05-14 EP disclosed
US-6548096-B1 Aspartyl dipeptide ester derivatives and sweeteners AJINOMOTO CO., INC. (JP) 2003-04-15 US disclosed
US-20020133045-A1 Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2002-09-19 US disclosed
WO-2002072709-A1 A PROCESS FOR THE PREPARATION OF SUBSTITUTED TRANS-CINNAMALDEHYDE, A NATURAL YELLOW DYE, FROM PHENYLPROPANE DERIVATIVES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2002-09-19 WO disclosed
EP-1070726-A1 ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS Ajinomoto Co., Inc. (JP) 2001-01-24 EP disclosed
EP-1045842-A2 METHODS OF USE AND COMPOSITIONS FOR BENZYLIDENE- AND CINNAMYLIDENE-ANABASEINES University of Florida (US) 2000-10-25 EP disclosed
US-5977144-A Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines UNIVERSITY OF FLORIDA (US) 1999-11-02 US disclosed
WO-1999010338-A2 BENZYLIDENE- AND CINNAMYLIDENE-ANABASEINES AS NEURONAL NICOTINIC ALPHA-7 RECEPTOR AGONISTS UNIVERSITY OF FLORIDA (US) 1999-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220226340-A1 CASEIN KINASE 1 INHIBITORS FOR USE IN THE TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION SUCH AS MUSCULAR DYSTROPHY AND CANCER CSNK1A1, CSNK1G3, CSNK1G1 CYP1A2 4828/4885CYP1A1 4753/4885CYP1B1 4758/4885
US-20200190024-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT PRKAA1, PRKAA2, PRKAG1 CYP1A2 4142/4885CYP1A1 4083/4885CYP1B1 4227/4885
US-20250376441-A1 NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT PRKAA1, PRKAA2, PRKAG1 CYP1A2 4142/4885CYP1A1 4083/4885CYP1B1 4227/4885
US-20020133045-A1 Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives CBR3, DDT, DHODH CYP1A2 1016/4885CYP1A1 881/4885CYP1B1 1708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.