Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388551 | 0.78 | GPR119 (0.59) | GPR119GPR183KCNH2 | |
| SCHEMBL460939 | 0.78 | MAPK8 (0.42) | GPR119CNR2KCNH2 | |
| SCHEMBL1091984 | 0.77 | GPR119 (0.47) | GPR119GPR183CNR2 | |
| SCHEMBL1093027 | 0.76 | GPR119 (0.39) | GPR119GPR183CNR2 | |
| SCHEMBL1092389 | 0.75 | GPR119 (0.54) | GPR119GPR183 | |
| SCHEMBL21770159 | 0.75 | LMNA (0.50) | GPR119SMO | |
| SCHEMBL462581 | 0.74 | GPR119 (0.49) | GPR119GPR183CNR2KCNH2 | |
| SCHEMBL1092705 | 0.74 | GPR119 (0.48) | GPR119GPR183 | |
| SCHEMBL870757 | 0.74 | GPR119 (0.73) | GPR119GPR183CNR2 | |
| SCHEMBL2371485 | 0.74 | GPR119 (0.56) | GPR119GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |