Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | CRHBP | P24387 | 2/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
| ▸ | ITGAL | P20701 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14501838 | 0.95 | MAPT (0.53) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL15982278 | 0.95 | MAPT (0.53) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL15981301 | 0.95 | MAPT (0.53) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL92786 | 0.89 | MEN1 (0.53) | LMNASMN1; SMN2HTTCYP2D6MAPT | |
| SCHEMBL25018796 | 0.83 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL25821224 | 0.82 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL19441506 | 0.82 | LMNA (0.53) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL12826601 | 0.82 | MEN1 (0.47) | LMNASMN1; SMN2CYP2D6MAPTGAA | |
| SCHEMBL8918332 | 0.82 | NPC1 (0.47) | LMNASMN1; SMN2CYP2D6MAPTGAA | |
| SCHEMBL20225724 | 0.81 | CD274 (0.54) | LMNASMN1; SMN2HTTCYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289457-A1 | PEPTIDE OLIGONUCLEOTIDE CONJUGATES | AVI BIOPHARMA, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120065169-A1 | OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065169-A1 | OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | NSUN2, UPF1, RTCB | LMNA 2297/4885SMN1; SMN2 146/4885CRHBP 826/4885 |
| US-20120289457-A1 | PEPTIDE OLIGONUCLEOTIDE CONJUGATES | SNRPE, SMN1; SMN2, UPF1 | LMNA 2744/4885SMN1; SMN2 2/4885CRHBP 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.