Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072133 | 0.78 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL15265113 | 0.75 | SRC (0.68) | MAPTLMNAKMT2AHTTBRD4 | |
| SCHEMBL2070607 | 0.71 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL20224829 | 0.71 | PARP1 (0.44) | MAPTLMNAKMT2AHTTPARP1 | |
| SCHEMBL15265574 | 0.71 | ALDH1A1 (0.44) | MAPTLMNAKMT2AHTTPARP1 | |
| SCHEMBL20224898 | 0.71 | CDK2 (0.44) | MAPTLMNAKMT2AHTTPARP1 | |
| SCHEMBL2069734 | 0.70 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL13838861 | 0.70 | CRHR1 (0.51) | CRHR1ALDH1A1GAA | |
| SCHEMBL2070441 | 0.68 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL2071976 | 0.68 | CRHR1 (0.60) | CRHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |