Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 9/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828152 | 0.84 | HTR6 (0.40) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL1268028 | 0.77 | BRD4 (0.41) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL4658373 | 0.74 | SMN1; SMN2 (0.33) | BRD4HTR2AHTR2CSMN1; SMN2TAAR1 | |
| SCHEMBL12675766 | 0.73 | HTR6 (0.39) | BRD4DRD2HTR2AHTR7ALDH1A1 | |
| SCHEMBL1266871 | 0.72 | BRD4 (0.58) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL15607451 | 0.72 | BRD4 (0.43) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL1267361 | 0.71 | HTR6 (0.40) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL1266811 | 0.71 | BRD4 (0.40) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL1268061 | 0.70 | KDM4E (0.45) | BRD4DRD2HTR2AHTR7CYP3A4 | |
| SCHEMBL2600003 | 0.70 | HTR6 (0.41) | BRD4DRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063888-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |