Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 10/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070180 | 0.94 | ATM (0.43) | CXCR2CXCR1L3MBTL1ATMTP53 | |
| SCHEMBL4971514 | 0.82 | HTT (0.44) | CXCR2CXCR1L3MBTL1ATMTP53 | |
| SCHEMBL23705971 | 0.74 | RXFP1 (0.51) | CXCR2CXCR1GAAMEN1NPC1 | |
| SCHEMBL4969475 | 0.73 | CXCR2 (0.46) | CXCR2CXCR1L3MBTL1ATMGAA | |
| SCHEMBL14157620 | 0.72 | LMNA (0.46) | CXCR2CXCR1L3MBTL1HTTMEN1 | |
| SCHEMBL4675699 | 0.70 | PDK1 (0.50) | CXCR2CXCR1HTTMEN1NPC1 | |
| SCHEMBL30797039 | 0.70 | PDK1 (0.50) | CXCR2CXCR1HTTMEN1NPC1 | |
| SCHEMBL11731600 | 0.69 | NPC1 (0.60) | GAAANPEPHTTNPC1LMNA | |
| SCHEMBL4969948 | 0.69 | CXCR2 (0.45) | CXCR2CXCR1TP53MDM4HTT | |
| SCHEMBL3742208 | 0.68 | SMN1; SMN2 (0.63) | GAAHTTMEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |