SCHEMBL4628906

SCHEMBL4628906

O=C(NCc1ccccc1)c1[c][c]ccc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.50
METAP2 P50579 1/20 0.50
HDAC2 Q92769 2/20 0.49
HDAC8 Q9BY41 2/20 0.49
HDAC6 Q9UBN7 2/20 0.49
TSHR P16473 1/20 0.49
HPGD P15428 3/20 0.47
LMNA P02545 2/20 0.47
GAA P10253 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MMP13 P45452 1/20 0.46
CHRNB2 P17787 1/20 0.46
CHRNB4 P30926 1/20 0.46
CHRNA3 P32297 1/20 0.46
CHRNA4 P43681 1/20 0.46
APEX1 P27695 1/20 0.46
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TP53 P04637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4628502 0.83 NPSR1 (0.56) KMT2ATSHRHPGDLMNAGAA
SCHEMBL1900364 0.81 KMT2A (0.54) KMT2AMETAP2HDAC2HDAC8HDAC6
SCHEMBL10387186 0.73 CYP1A2 (0.52) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL14862482 0.72 TSHR (0.49) KMT2AMETAP2HDAC2HDAC8HDAC6
SCHEMBL7573931 0.72 HSP90AA1 (0.50) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL10389701 0.72 HPGD (0.58) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL1900238 0.71 HDAC6 (0.67) HDAC2HDAC8HDAC6TSHRHPGD
SCHEMBL11901003 0.71 KMT2A (0.89) KMT2AMETAP2HDAC2HDAC8HDAC6
SCHEMBL457082 0.71 HDAC6 (0.79) HDAC2HDAC8HDAC6HPGDLMNA
SCHEMBL11900090 0.71 HDAC6 (0.85) HDAC2HDAC8HDAC6TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633716-A4 BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2008-03-26 EP claimed
EP-1633716-A2 BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS Bristol-Myers Squibb Company (US) 2006-03-15 EP claimed
WO-2004094372-A2 COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-11-04 WO claimed
EP-1633716-A4 BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2008-03-26 EP disclosed
EP-1633716-A2 BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS Bristol-Myers Squibb Company (US) 2006-03-15 EP disclosed
WO-2004094372-A2 COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-11-04 WO disclosed