Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NMT2 | O60551 | 6/20 | 0.47 |
| ▸ | NMT1 | P30419 | 6/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608031 | 0.88 | RAB9A (0.65) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL10738691 | 0.88 | RAB9A (0.74) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL10743101 | 0.85 | RAB9A (0.62) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL3610943 | 0.85 | RAB9A (0.62) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL6871537 | 0.85 | RAB9A (0.62) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL3614948 | 0.85 | RAB9A (0.62) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL10738818 | 0.84 | RAB9A (0.60) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL10741846 | 0.84 | RAB9A (0.60) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL3608901 | 0.84 | RAB9A (0.60) | RAB9ANPC1MAPTL3MBTL1KDM4E | |
| SCHEMBL9868567 | 0.83 | RAB9A (0.59) | RAB9ANPC1MAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |