Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 4/20 | 0.44 |
| ▸ | TEC | P42680 | 3/20 | 0.44 |
| ▸ | BMX | P51813 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459116 | 0.81 | PIK3CD (0.59) | METAP2BTKTECBMXBLK | |
| SCHEMBL1118909 | 0.80 | PIK3CD (0.53) | METAP2BTKTECBMXBLK | |
| SCHEMBL31409300 | 0.78 | METAP2 (0.55) | METAP2BTKTECBMXNOS1 | |
| SCHEMBL4560363 | 0.78 | MKNK1 (0.50) | LIMK1 | |
| SCHEMBL27399246 | 0.78 | PIK3CA (0.46) | METAP2BTKTECBMXBLK | |
| SCHEMBL19664493 | 0.77 | CCNA2 (0.49) | BTKTECBMXNOS1BLK | |
| SCHEMBL26675049 | 0.76 | BTK (0.46) | METAP2BTKTECBMXNOS1 | |
| SCHEMBL31437268 | 0.76 | BTK (0.46) | METAP2BTKTECBMXNOS1 | |
| Hydrochloric Acid SCHEMBL19664473 | 0.76 | CCNA2 (0.48) | BTKTECBMXNOS1BLK | |
| SCHEMBL28501811 | 0.75 | PARP1 (0.46) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |