Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | MLYCD | O95822 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628683 | 0.91 | SCN5A (0.58) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4629427 | 0.91 | SCN5A (0.70) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4627587 | 0.90 | SCN5A (0.69) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4628718 | 0.87 | ALDH1A1 (0.62) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4628372 | 0.86 | ALDH1A1 (0.61) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4628964 | 0.86 | SCN5A (0.65) | NPC1RAB9ASCN5ASCN2AMLYCD | |
| SCHEMBL4628488 | 0.85 | MAPT (0.65) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL4627416 | 0.84 | NPC1 (0.67) | NPC1RAB9AHSP90AA1SCN5ASCN2A | |
| SCHEMBL11176654 | 0.84 | NPC1 (0.90) | NPC1RAB9AHSP90AA1MLYCDPOLB | |
| SCHEMBL8582841 | 0.84 | NAAA (0.69) | ALDH1A1POLBSMN1; SMN2HDAC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | disclosed |
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | GBA1, CTSA, GAA | NPC1 140/4885RAB9A 617/4885HSP90AA1 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.