SCHEMBL4629632

SCHEMBL4629632

NC(=O)C(=O)C1CCNCC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 2/20 0.54
TSHR P16473 2/20 0.54
GABRG2 P18507 2/20 0.54
GABRB3 P28472 2/20 0.54
GABRA5 P31644 2/20 0.54
GABRA3 P34903 2/20 0.54
GABRA2 P47869 2/20 0.54
GABRA6 Q16445 2/20 0.54
GABRP O00591 1/20 0.54
GABRD O14764 1/20 0.54
GABRB1 P18505 1/20 0.54
GABRB2 P47870 1/20 0.54
GABRA4 P48169 1/20 0.54
GABRE P78334 1/20 0.54
PMP22 Q01453 1/20 0.54
GABRG1 Q8N1C3 1/20 0.54
GABRG3 Q99928 1/20 0.54
GABRQ Q9UN88 1/20 0.54
NOS2 P35228 1/20 0.52
KMT2A Q03164 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4630912 0.86 KDM4E (0.52) GABRA1TSHRGABRG2GABRB3GABRA5
SCHEMBL4755087 0.86 GABRA1 (0.50) GABRA1TSHRGABRG2GABRB3GABRA5
SCHEMBL2468568 0.81
SCHEMBL3949668 0.80 GABRA1 (0.54) GABRA1TSHRGABRG2GABRB3GABRA5
SCHEMBL1298 0.79
SCHEMBL4539455 0.79 GABRA1 (0.59) GABRA1TSHRGABRG2GABRB3GABRA5
SCHEMBL18519653 0.78 TSHR (0.46) GABRA1TSHRGABRG2GABRB3GABRA5
SCHEMBL19815905 0.77 TSHR (0.64) GABRA1TSHRGABRG2GABRB3GABRA5
Hydrochloric Acid SCHEMBL2674808 0.77 GABRA1 (0.56) GABRA1TSHRGABRG2GABRB3GABRA5
Hydrochloric Acid SCHEMBL4716510 0.77 GABRA1 (0.56) GABRA1TSHRGABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008133344-A2 PIPERIDINE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-11-06 WO disclosed
EP-1919907-A2 HETEROCYCLIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-05-14 EP disclosed
WO-2007026959-A2 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-03-08 WO disclosed
EP-1358157-A1 CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS AstraZeneca AB (SE) 2003-11-05 EP disclosed
WO-2002051806-A1 CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS ASTRAZENECA AB (SE) 2002-07-04 WO disclosed