Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.59 |
| ▸ | GABRP | O00591 | 1/20 | 0.59 |
| ▸ | GABRD | O14764 | 1/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.59 |
| ▸ | GABRE | P78334 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4716510 | 0.97 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL2674808 | 0.97 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL29868978 | 0.95 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL4002484 | 0.91 | KMT2A (0.69) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Benzene SCHEMBL16741898 | 0.91 | GABRP (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Formic Acid SCHEMBL28944845 | 0.91 | GABRA5 (0.50) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Acetic Acid SCHEMBL3154824 | 0.89 | GABRP (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Methylene Chloride SCHEMBL27877964 | 0.89 | GABRP (0.48) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Maleic Acid SCHEMBL4261390 | 0.87 | TSHR (0.52) | GABRA1TSHRGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534889-B2 | For reduced motility of gastrointestinal tract; irritable bowel syndrome (IBS), chronic constipation, dyspepsia, reflux disease; 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{3-[(2-ethylsulfanylethyl)methanesulfonylamino]-2-hydroxypropyl}-8-aza-bicyclo[3.2.1]oct-3-yl)amide | THERAVANCE, INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-20080255187-A1 | 5-HT4 RECEPTOR AGONIST COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255187-A1 | 5-HT4 RECEPTOR AGONIST COMPOUNDS | HTR4, HTR5A, HTR1A | GABRA1 524/4885TSHR 214/4885GABRG2 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.