Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | DPYD | Q12882 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801644 | 0.69 | ALDH1A1 (0.64) | ALDH1A1ATAD2LMNADPYDMAPT | |
| SCHEMBL11600094 | 0.69 | — | — | |
| SCHEMBL8075442 | 0.61 | — | — | |
| SCHEMBL5146148 | 0.60 | — | — | |
| SCHEMBL16266667 | 0.60 | — | — | |
| SCHEMBL25367974 | 0.59 | KDM3B (0.37) | ALDH1A1 | |
| SCHEMBL15920864 | 0.59 | — | — | |
| SCHEMBL5503705 | 0.59 | NISCH (0.37) | ALDH1A1CYP19A1MTORSMN1; SMN2 | |
| SCHEMBL5612855 | 0.59 | — | — | |
| SCHEMBL3553811 | 0.59 | ATAD2 (0.50) | ALDH1A1ATAD2LMNADPYDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1573000-B1 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| EP-1573000-A2 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | AstraZeneca AB (SE) | 2005-09-14 | — | — | EP | disclosed |
| US-20050037478-A1 | Crystal structure of glutamate racemase (MurI) | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | US | disclosed |
| WO-2004061097-A2 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | ASTRAZENECA AB (SE) | 2004-07-22 | — | — | WO | disclosed |