Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 2/20 | 0.37 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953504 | 0.77 | HTR1B (0.60) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| SCHEMBL4629792 | 0.77 | PTGIR (0.57) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| SCHEMBL4629571 | 0.76 | TAAR1 (0.48) | HTR1BHTR1DADRA2AADRA1DADRA1A | |
| SCHEMBL9575262 | 0.73 | PTGIR (0.83) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| SCHEMBL3169344 | 0.68 | PTGIR (0.64) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| SCHEMBL5803714 | 0.67 | PTGIR (1.00) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| Hydrochloric Acid SCHEMBL4692716 | 0.66 | PTGIR (0.72) | PTGIRADRA2AADRA2CADRA2BGPR65 | |
| SCHEMBL4992378 | 0.66 | ALDH1A1 (0.61) | PTGIRHTR1BHTR1DADRA2AADRA1D | |
| SCHEMBL4687666 | 0.65 | PTGIR (0.74) | PTGIRADRA2AADRA1DADRA1AADRA1B | |
| SCHEMBL10777223 | 0.64 | HTR1B (0.57) | PTGIRHTR1BHTR1DADRA2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |