Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 3/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953504 | 0.89 | HTR1B (0.60) | PTGIRHTR1BHTR1DADRA1AADRA2A | |
| SCHEMBL9575262 | 0.80 | PTGIR (0.83) | PTGIRHTR1BRAD52HTR1DADRA1A | |
| SCHEMBL953972 | 0.78 | RAD52 (0.82) | PTGIRHTR1BRAD52HTR1DADRA1A | |
| SCHEMBL4629802 | 0.77 | PTGIR (0.49) | PTGIRHTR1BRAD52HTR1DADRA1A | |
| SCHEMBL4992378 | 0.76 | ALDH1A1 (0.61) | PTGIRHTR1BRAD52HTR1DADRA1A | |
| SCHEMBL5803714 | 0.73 | PTGIR (1.00) | PTGIRHTR1BRAD52HTR1DADRA1A | |
| SCHEMBL26078623 | 0.72 | NISCH (0.58) | HTR1BHTR1DADRA1AADRA2AADRA1D | |
| SCHEMBL4629569 | 0.71 | RAD52 (0.61) | HTR1BRAD52HTR1DADRA1AADRA2A | |
| SCHEMBL7806407 | 0.70 | CYP19A1 (0.69) | ADRA1ATAAR1IDO1DHFR | |
| SCHEMBL26078498 | 0.70 | HTR1B (0.55) | PTGIRHTR1BHTR1DADRA1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |