Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24322673 | 0.84 | ALDH1A1 (0.71) | KDM4EALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL2677286 | 0.79 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNAL3MBTL1NAMPT | |
| SCHEMBL22875137 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1LMNAL3MBTL1NAMPT | |
| SCHEMBL14211199 | 0.76 | CHRNB2 (0.49) | KDM4EALDH1A1LMNAL3MBTL1CHRNB2 | |
| SCHEMBL2444480 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL3696171 | 0.74 | DDB1 (0.50) | KDM4EALDH1A1DDB1CRBNCHRNB2 | |
| SCHEMBL15014609 | 0.74 | ALDH1A1 (0.56) | KDM4EALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL16645175 | 0.73 | DDB1 (0.47) | DDB1CRBNL3MBTL1CHRNB2CHRNA3 | |
| SCHEMBL16207650 | 0.73 | DDB1 (0.53) | DDB1CRBNCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL13429753 | 0.73 | DDB1 (0.49) | KDM4EALDH1A1DDB1CRBNCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |