Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630350 | 0.89 | PRCP (0.39) | PRCPCES2CES1 | |
| SCHEMBL28874795 | 0.87 | PRCP (0.41) | PRCPCES2CES1 | |
| SCHEMBL4630457 | 0.86 | PRCP (0.44) | HSD17B10PRCPCES2CES1 | |
| SCHEMBL10067948 | 0.84 | CHRNB2 (0.33) | PRCPCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL4659265 | 0.84 | CHRNB2 (0.33) | PRCPCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL10067949 | 0.84 | CHRNB2 (0.33) | PRCPCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL8386986 | 0.83 | — | — | |
| SCHEMBL4630220 | 0.82 | SLC6A1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL2655644 | 0.82 | CHRNB2 (0.32) | PRCPCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL27468849 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |