Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | BID | P55957 | 3/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.48 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630157 | 0.98 | NR1H2 (0.48) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL4630656 | 0.93 | PDCD1 (0.43) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL3563200 | 0.86 | PDCD1 (0.46) | PPARASOAT1PTPN1 | |
| SCHEMBL2303757 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL760598 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL761403 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL30631255 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL251097 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL8521601 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 | |
| SCHEMBL3726514 | 0.84 | LIPG (0.55) | NR1H2NR1H3PPARABIDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |