Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 9/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 9/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 9/20 | 0.45 |
| ▸ | MAOA | P21397 | 7/20 | 0.45 |
| ▸ | MAOB | P27338 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953164 | 0.87 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| SCHEMBL954219 | 0.84 | NISCH (0.56) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL953759 | 0.77 | ADRA2B (0.46) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| SCHEMBL954357 | 0.76 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CHTR1ASLC6A4 | |
| SCHEMBL952920 | 0.75 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL953349 | 0.73 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CHTR1ANISCH | |
| SCHEMBL954708 | 0.73 | NISCH (0.45) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL953296 | 0.73 | NISCH (0.53) | ADRA2AADRA2BADRA2CHTR1ANISCH | |
| SCHEMBL954868 | 0.73 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL954884 | 0.72 | NISCH (0.49) | ADRA2AADRA2BADRA2CHTR1ANISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |