Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.51 |
| ▸ | RARG | P13631 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190628 | 0.88 | RARB (0.63) | RARBRARGKMT2AMEN1POLB | |
| SCHEMBL4326646 | 0.87 | RARB (0.62) | RARBRARGKMT2AMEN1L3MBTL1 | |
| SCHEMBL4184893 | 0.87 | RARB (0.62) | RARBRARGKMT2AMEN1L3MBTL1 | |
| SCHEMBL4192389 | 0.80 | RARB (0.61) | RARBRARGKMT2AMEN1RARA | |
| SCHEMBL13779497 | 0.69 | KMT2A (0.43) | KMT2AMEN1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL4187456 | 0.69 | RARB (0.62) | RARBRARGKMT2AMEN1RARA | |
| SCHEMBL2946732 | 0.69 | L3MBTL1 (0.78) | RARBRARGKMT2AMEN1L3MBTL1 | |
| SCHEMBL4196901 | 0.69 | RARB (0.92) | RARBRARGKMT2AMEN1TSHR | |
| SCHEMBL4190671 | 0.67 | RARB (1.00) | RARBRARGRARA | |
| SCHEMBL5659943 | 0.67 | KMT2A (0.52) | KMT2AMEN1L3MBTL1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907347-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | Arcadia Pharmaceuticals Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009083-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2007-01-18 | — | — | WO | disclosed |