Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.60 |
| ▸ | DRD2 | P14416 | 16/20 | 0.60 |
| ▸ | HTR2A | P28223 | 16/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507046 | 0.87 | DRD2 (0.56) | HTR1ADRD2HTR2A | |
| SCHEMBL10228320 | 0.84 | DRD2 (0.61) | HTR1ADRD2HTR2A | |
| SCHEMBL29433199 | 0.84 | DRD2 (0.75) | HTR1ADRD2HTR2A | |
| SCHEMBL294174 | 0.83 | DRD2 (0.55) | HTR1ADRD2HTR2A | |
| SCHEMBL4574005 | 0.83 | DRD2 (0.64) | HTR1ADRD2HTR2A | |
| Oxalic Acid SCHEMBL31256010 | 0.82 | HTR1A (0.53) | HTR1ADRD2HTR2A | |
| SCHEMBL293666 | 0.82 | DRD2 (0.65) | HTR1ADRD2HTR2A | |
| SCHEMBL22302867 | 0.81 | DRD2 (0.63) | HTR1ADRD2HTR2A | |
| SCHEMBL12559512 | 0.81 | DRD2 (0.57) | HTR1ADRD2HTR2A | |
| SCHEMBL293734 | 0.81 | DRD2 (0.67) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| EP-1869025-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |
| WO-2006112464-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |