Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.65 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL463331 | 0.93 | AGTR1 (0.56) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL19357208 | 0.93 | AGTR1 (0.73) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL29682351 | 0.93 | AGTR1 (0.73) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL29508236 | 0.93 | AGTR1 (0.73) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL3938 | 0.93 | AGTR1 (0.73) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL7292788 | 0.92 | AGTR1 (0.72) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL16237819 | 0.92 | AGTR1 (0.72) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL28786878 | 0.92 | AGTR1 (0.72) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL5507160 | 0.92 | AGTR1 (0.72) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| Candesartan SCHEMBL27825805 | 0.92 | AGTR1 (0.72) | AGTR1ABCB11EGFRERBB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012033983-A2 | CANDESARTAN PHARMACEUTICAL COMPOSITIONS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-15 | — | — | WO | disclosed |
| WO-2010126168-A2 | SOLID PREPARATION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-04 | — | — | WO | disclosed |
| WO-2007028524-A2 | USE OF A DERIVATIVE OF IMIDAZOLE FOR THE TREATMENT OF LEUKOTRIENE RELATED DISORDERS | PROUS INSTITUTE FOR BIOMEDICAL RESEARCH S.A. (ES) | 2007-03-15 | — | — | WO | disclosed |
| WO-2005123721-A2 | AMORPHOUS AND POLYMORPHIC FORMS OF CANDESARTAN CILEXETIL | RANBAXY LABORATORIES LIMITED (IN) | 2005-12-29 | — | — | WO | disclosed |
| CN-1047518-C | Pharmaceutical compositions for oral use and method of preparing them | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-12-22 | — | — | CN | disclosed |
| US-6004989-A | ETHYL 2-ETHOXY-1-(2'-1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL) BENZIMIDAZOLE-7-CARBOXYLATE AND SALTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0914158-A2 | PHARMACEUTICAL COMBINATION CONTAINING A COMPOUND HAVING ANGIOTENSIN II AND ANTAGONISTIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997037688-A2 | PHARMACEUTICAL COMBINATION CONTAINING A COMPOUND HAVING ANGIOTENSIN II AND ANTAGONISTIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-16 | — | — | WO | disclosed |