Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138994 | 0.67 | MAPT (0.56) | MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL21537437 | 0.66 | KDM4E (0.59) | IKBKBKMOAURKAHSP90AA1PRKACA | |
| SCHEMBL3140138 | 0.65 | MAPT (0.54) | MEN1KMT2AGAAMAPTL3MBTL1 | |
| SCHEMBL21164006 | 0.65 | HSP90AA1 (0.70) | IKBKBKMOAURKAHSP90AA1PRKACA | |
| SCHEMBL15876512 | 0.65 | MEN1 (0.55) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL28712359 | 0.65 | PIK3CA (0.46) | MEN1KMT2AMAP4K4MAPTLMNA | |
| SCHEMBL3135428 | 0.65 | MAPT (0.61) | MEN1KMT2AGAAMAPTL3MBTL1 | |
| SCHEMBL3134626 | 0.64 | MAPT (0.53) | MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL28749623 | 0.64 | MCL1 (0.46) | KMOMEN1KMT2AKDM4EMAPT | |
| SCHEMBL2036371 | 0.64 | MAPK8 (0.56) | CAMK2DKMOMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |