Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PRKX | P51817 | 2/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530347 | 0.85 | ROCK1 (0.61) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL4523811 | 0.81 | ROCK2 (0.62) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL27723735 | 0.81 | ROCK2 (0.62) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL4526393 | 0.81 | ROCK2 (0.62) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL2802593 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL2802584 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL10260826 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| Hydrochloric Acid SCHEMBL4525075 | 0.79 | ROCK2 (0.62) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL10259979 | 0.78 | ROCK2 (0.58) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 | |
| SCHEMBL10260376 | 0.78 | ROCK2 (0.58) | ROCK2ROCK1RPS6KA5PRKACAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |