Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602214 | 0.87 | EPHX1 (0.41) | EPHX1ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL2222653 | 0.85 | EPHX1 (0.45) | EPHX1ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL4603603 | 0.82 | CHRNB2 (0.38) | EPHX1ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL288502 | 0.80 | HRH3 (0.48) | EPHX1PLA2G2CNPC1HPGDRAB9A | |
| SCHEMBL26626453 | 0.80 | HRH3 (0.48) | EPHX1PLA2G2CNPC1HPGDRAB9A | |
| SCHEMBL283254 | 0.80 | HRH3 (0.48) | EPHX1PLA2G2CNPC1HPGDRAB9A | |
| SCHEMBL7447157 | 0.79 | FOLH1 (0.51) | — | |
| SCHEMBL6168369 | 0.77 | KMT2A (0.49) | PLA2G2CMAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL7006306 | 0.77 | KMT2A (0.49) | PLA2G2CMAPK1SMN1; SMN2EPHX2 | |
| SCHEMBL4685971 | 0.77 | SIRT2 (0.43) | EPHX1PLA2G2CNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924568-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |