Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604013 | 0.83 | NOS2 (0.50) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL4604010 | 0.83 | NOS2 (0.50) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL4632518 | 0.78 | NOS2 (0.44) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL4632522 | 0.78 | NOS2 (0.44) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL30088615 | 0.74 | NOS2 (0.36) | NOS2NOS3NOS1NOD1UTS2R | |
| SCHEMBL1527394 | 0.73 | NOS2 (0.65) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL25629375 | 0.73 | NOS2 (0.65) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL1527395 | 0.73 | NOS2 (0.65) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL4603896 | 0.72 | NOS2 (0.40) | NOS2NOS3NOS1MEN1CYP2C19 | |
| SCHEMBL3091594 | 0.72 | NOS2 (0.40) | NOS2NOS3NOS1MEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924568-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |