Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18919374 | 0.85 | EPHX1 (0.52) | ALDH1A1MAPTKDM4EMAPK1EPHX1 | |
| SCHEMBL16824229 | 0.79 | EPHX1 (0.59) | ALDH1A1SMN1; SMN2HPGDEPHX1ACHE | |
| SCHEMBL14772125 | 0.76 | DNM1 (0.71) | DNM1ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL11596956 | 0.76 | ACHE (0.66) | DNM1ACHE | |
| Hydrochloric Acid SCHEMBL11596954 | 0.74 | ACHE (0.64) | DNM1ACHE | |
| SCHEMBL11650927 | 0.74 | EPHX1 (0.53) | ALDH1A1SMN1; SMN2HPGDEPHX1ACHE | |
| SCHEMBL12184048 | 0.74 | DNM1 (0.46) | DNM1EPHX1ACHE | |
| SCHEMBL9177559 | 0.72 | EPHX1 (0.44) | ALDH1A1SMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL5763848 | 0.72 | ACHE (0.53) | ALDH1A1SMN1; SMN2EPHX1ACHEL3MBTL1 | |
| SCHEMBL21226035 | 0.71 | DNM1 (0.74) | DNM1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924568-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |