Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 9/20 | 0.47 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703820 | 0.93 | MAPT (0.59) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL273427 | 0.88 | FTO (0.59) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL284851 | 0.87 | MAPT (0.65) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL9474742 | 0.87 | FTO (0.58) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL988945 | 0.85 | ALDH1A1 (0.54) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL5694289 | 0.84 | FTO (0.46) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL9844359 | 0.81 | FTO (0.43) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL5174468 | 0.81 | FTO (0.75) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL15128906 | 0.80 | FTO (0.63) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL17515090 | 0.79 | ALDH1A1 (0.55) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924709-A1 | METHODS FOR DETERMINING PROBABILITY OF AN ADVERSE OR FAVORABLE REACTION TO A NIACIN RECEPTOR AGONIST | Arena Pharmaceuticals, Inc. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007021744-A1 | METHODS FOR DETERMINING PROBABILITY OF AN ADVERSE OR FAVORABLE REACTION TO A NIACIN RECEPTOR AGONIST | ARENA PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | WO | disclosed |