Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914867 | 0.86 | TDP1 (0.36) | TDP1 | |
| Bromide SCHEMBL25226061 | 0.84 | TDP1 (0.35) | TDP1 | |
| SCHEMBL14603796 | 0.84 | TDP1 (0.35) | TDP1 | |
| Hydrochloric Acid SCHEMBL2153907 | 0.84 | TDP1 (0.35) | TDP1 | |
| Hydrochloric Acid SCHEMBL1421974 | 0.78 | — | — | |
| SCHEMBL1422220 | 0.76 | TDP1 (0.30) | TDP1 | |
| SCHEMBL4242152 | 0.71 | TDP1 (0.36) | TDP1 | |
| SCHEMBL2220314 | 0.71 | TAAR1 (0.39) | TDP1 | |
| SCHEMBL28240129 | 0.67 | TDP1 (0.33) | TDP1 | |
| SCHEMBL755582 | 0.65 | TAAR1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836184-B1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | HONEYWELL INT INC (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1836184-A1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | Honeywell International Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| US-7205414-B2 | Process for the Kumada coupling reaction | HONEYWELL INTERNATIONAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2006076150-A1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | HONEYWELL INTERNATIONAL INC. (US) | 2006-07-20 | — | — | WO | disclosed |
| US-20060155134-A1 | Process for the kumada coupling reaction | HONEYWELL INTERNATIONAL INC. | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060155134-A1 | Process for the kumada coupling reaction | KMT5A, KMT5C, KCNT1 | TDP1 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.