Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631770 | 1.00 | ABL1 (0.48) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL4633324 | 0.99 | ABL1 (0.47) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL4632616 | 0.97 | KDR (0.46) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL4633604 | 0.92 | HDAC1 (0.46) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL4632530 | 0.89 | KDR (0.44) | ABL1BCRKDRHDAC1HDAC6 | |
| SCHEMBL2439137 | 0.87 | ABL1 (0.61) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL2433994 | 0.87 | ABL1 (0.61) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL3085713 | 0.87 | ABL1 (0.53) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL3106720 | 0.87 | ABL1 (0.53) | ABL1BCRHRH3KDRHDAC1 | |
| SCHEMBL2431020 | 0.86 | ABL1 (0.60) | ABL1BCRHRH3KDRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |