Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633324 | 0.98 | ABL1 (0.47) | KDRABL1BCRHRH3KIT | |
| SCHEMBL4632623 | 0.97 | ABL1 (0.48) | KDRABL1BCRHRH3KIT | |
| SCHEMBL4631770 | 0.97 | ABL1 (0.48) | KDRABL1BCRHRH3KIT | |
| SCHEMBL4633604 | 0.93 | HDAC1 (0.46) | KDRABL1BCRHRH3KIT | |
| SCHEMBL4632530 | 0.90 | KDR (0.44) | KDRABL1BCRKITFLT3 | |
| SCHEMBL2431903 | 0.87 | ABL1 (0.58) | KDRABL1BCRHRH3KIT | |
| SCHEMBL3085794 | 0.86 | ABL1 (0.50) | KDRABL1BCRHRH3KIT | |
| SCHEMBL2431020 | 0.85 | ABL1 (0.60) | KDRABL1BCRHRH3KIT | |
| SCHEMBL3104562 | 0.84 | ABL1 (0.52) | KDRABL1BCRHRH3KIT | |
| SCHEMBL2433994 | 0.84 | ABL1 (0.61) | KDRABL1BCRHRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |