Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | BCR | P11274 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632616 | 0.93 | KDR (0.46) | HDAC1TBK1KDRKITFLT3 | |
| SCHEMBL4633324 | 0.93 | ABL1 (0.47) | HDAC1TBK1KDRF10KIT | |
| SCHEMBL4632623 | 0.92 | ABL1 (0.48) | HDAC1TBK1KDRF10KIT | |
| SCHEMBL4631770 | 0.92 | ABL1 (0.48) | HDAC1TBK1KDRF10KIT | |
| SCHEMBL4632530 | 0.88 | KDR (0.44) | HDAC1KDRKITFLT3ABL1 | |
| SCHEMBL4633593 | 0.87 | HDAC1 (0.48) | HDAC1IKBKETBK1KDRF10 | |
| SCHEMBL4632682 | 0.82 | HDAC6 (0.38) | HDAC1KITFLT3FGFR1 | |
| SCHEMBL4632607 | 0.81 | HDAC1 (0.49) | HDAC1IKBKETBK1KDRFLT3 | |
| SCHEMBL4633619 | 0.81 | NPC1 (0.47) | — | |
| SCHEMBL2431903 | 0.80 | ABL1 (0.58) | HDAC1KDRKITFLT3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |