Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | PDE4A | P27815 | 7/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.43 |
| ▸ | TYK2 | P29597 | 7/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462124 | 0.80 | TTK (0.49) | TTK | |
| SCHEMBL463247 | 0.80 | TTK (0.47) | TTK | |
| SCHEMBL461988 | 0.80 | TTK (0.40) | PDE4DTYK2TTK | |
| SCHEMBL456319 | 0.79 | TTK (0.57) | TTK | |
| SCHEMBL12467108 | 0.76 | TTK (0.36) | TTKSYKFLT3 | |
| SCHEMBL456965 | 0.76 | ERN1 (0.40) | TTKFLT3 | |
| SCHEMBL462359 | 0.75 | TTK (0.42) | TTKSYK | |
| SCHEMBL457467 | 0.71 | TTK (0.40) | TTK | |
| SCHEMBL457970 | 0.71 | TTK (0.44) | TTK | |
| SCHEMBL9942420 | 0.71 | TTK (0.44) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |