Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698514 | 0.81 | ALDH1A1 (0.49) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL10851246 | 0.81 | ALDH1A1 (0.52) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL6357561 | 0.81 | DRD3 (0.51) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL1862779 | 0.81 | ALDH1A1 (0.49) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL20931184 | 0.78 | ALDH1A1 (0.47) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL4578025 | 0.78 | ALDH1A1 (0.47) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL236347 | 0.78 | CA12 (0.54) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL11720298 | 0.77 | ALDH1A1 (0.66) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL10422970 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1POLBGAASMN1; SMN2NPSR1 | |
| SCHEMBL946186 | 0.75 | CASP3 (0.50) | ALDH1A1CASP3CA12CA9GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076466-A1 | MODULATORS OF CULLIN 3 ADAPTOR KBTBD4 AS ANTI-CANCER COMPOUNDS | UNIVERSITE DE MONTREAL (CA) | 2022-10-26 | — | — | EP | disclosed |
| CN-114845719-A | Modulators of the CULLIN3 connexin kbbd 4 as anti-cancer compounds | 蒙特利尔大学 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021119834-A1 | MODULATORS OF CULLIN 3 ADAPTOR KBTBD4 AS ANTI-CANCER COMPOUNDS | UNIVERSITE DE MONTREAL (CA) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021119834-A1 | MODULATORS OF CULLIN 3 ADAPTOR KBTBD4 AS ANTI-CANCER COMPOUNDS | UNIVERSITE DE MONTREAL (CA) | 2021-06-24 | — | — | WO | disclosed |
| US-8772277-B2 | Nitrogen-containing heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-08 | — | — | US | disclosed |
| US-20130072467-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2013-03-21 | — | — | US | disclosed |
| WO-2013018929-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-07 | — | — | WO | disclosed |
| EP-1546098-B1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LAB LTD (IN) | 2008-05-28 | — | — | EP | disclosed |
| US-7265147-B2 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists | RANBAXY LABORATORIES LIMITED (IN) | 2007-09-04 | — | — | US | disclosed |
| US-20060122253-A1 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists | RANBAXY LABORATORIES LIMITED (IN) | 2006-06-08 | — | — | US | disclosed |
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |
| US-5308837-A | 5'-amine substituted adenosine analogs as immunosuppressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-05-03 | — | — | US | disclosed |
| WO-1993016073-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |
| EP-0472181-A2 | 5-Amine substituted adenosine analogs as immunosuppressants | MERRELL PHARMACEUTICALS INC. (US) | 1992-02-26 | — | — | EP | disclosed |
| EP-0358536-A2 | Novel S-adenosyl methionine decarboxylase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0351475-A1 | S-Adenosylmethionine decarboxylase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-24 | — | — | EP | disclosed |
| US-4657908-A | Carbonyl derivatives | ICI AMERICAS, INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0059597-B1 | GUANIDINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES HAVING HISTAMINE H-2 ANTAGONIST ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-04-23 | — | — | EP | disclosed |
| US-4496571-A | GUANIDINE DERIVATIVE | ICI AMERICAS INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0059597-A2 | Guanidino-substituted heterocyclic derivatives having histamine H-2 antagonist activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072467-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | ESRRA, ESRRB, ESR2 | ALDH1A1 785/4885POLB 2402/4885GAA 3154/4885 |
| US-20060122253-A1 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists | CHRM3, CHRM5, CHRM2 | ALDH1A1 738/4885POLB 3537/4885GAA 2900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.