Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | BAD | Q92934 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.38 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.38 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633542 | 0.99 | CXCR2 (0.47) | CXCR2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4634457 | 0.95 | CXCR2 (0.48) | CXCR2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4604123 | 0.86 | CXCR2 (0.49) | CXCR2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4605692 | 0.85 | CXCR2 (0.50) | CXCR2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4633943 | 0.84 | ABCC1 (0.43) | CXCR2ALDH1A1KMT2A | |
| SCHEMBL4605238 | 0.83 | CXCR2 (0.52) | CXCR2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4604559 | 0.83 | PPARA (0.52) | CXCR2ALDH1A1LMNAKMT2APTPN2 | |
| SCHEMBL4634474 | 0.83 | ABCC1 (0.44) | CXCR2ALDH1A1KMT2A | |
| SCHEMBL4633030 | 0.82 | CXCR2 (0.52) | CXCR2LMNAPPARA | |
| SCHEMBL4604246 | 0.82 | CXCR2 (0.53) | CXCR2ALDH1A1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-7375130-B2 | Antidiabetic compounds comprising benzofuran and benzothiophene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-05-20 | — | — | US | disclosed |
| US-20070078178-A1 | Antidiabetic compounds comprising benzofuran and benzothiophene derivatives | MERCK PATENT GMBH (DE) | 2007-04-05 | — | — | US | disclosed |
| EP-1685121-A1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005054225-A1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078178-A1 | Antidiabetic compounds comprising benzofuran and benzothiophene derivatives | GPR119, INSR, GLP1R | CXCR2 2534/4885ALDH1A1 668/4885MAPT 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.