⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432 | 0.96 | — | — | |
| Hydrogen Peroxide SCHEMBL28038876 | 0.93 | — | — | |
| SCHEMBL27817051 | 0.93 | — | — | |
| SCHEMBL27475050 | 0.93 | — | — | |
| SCHEMBL4632179 | 0.93 | — | — | |
| Ammonia Solution, Strong SCHEMBL29165044 | 0.90 | — | — | |
| Cyclopropane SCHEMBL27492181 | 0.87 | ALDH1A1 (0.48) | — | |
| Pyruvate SCHEMBL5054355 | 0.87 | ALDH1A1 (0.48) | — | |
| SCHEMBL28868431 | 0.84 | ALDH1A1 (0.52) | — | |
| SCHEMBL9207763 | 0.80 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830828-A4 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | ANTOSH & MEDURI HOLDING CORP (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1781108-A4 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2008-06-04 | — | — | EP | claimed |
| EP-1830828-A2 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | Antosh & Meduri Holding Corporation (US) | 2007-09-12 | — | — | EP | claimed |
| EP-1796460-A2 | USE OF METHYL PYRUVATE OR METHYL PYRUVIC ACID FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM AND FOR PROTECTING A HUMAN CENTRAL NERVOUS SYSTEM AGAINST NEURONAL DEGENERATION CAUSED BY DEFECTIVE INTRACELLULAR ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-06-20 | — | — | EP | claimed |
| EP-1781108-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006055764-A2 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | ANTOSH STANLEY C (US) | 2006-05-26 | — | — | WO | claimed |
| US-20060111442-A1 | Use of methyl pyruvate to increase cellular energy production downstream of glycolysis for the PARP-1 ablation of HIV without necrotic cell death caused by continuous, chronic PARP-1 activation through the concomitant depletion of ATP and NAD. | Antosh, Mr. Stanley (US) | 2006-05-25 | — | — | US | claimed |
| WO-2006028948-A2 | USE OF METHYL PYRUVATE OR METHYL PYRUVIC ACID FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM AND FOR PROTECTING A HUMAN CENTRAL NERVOUS SYSTEM AGAINST NEURONAL DEGENERATION CAUSED BY DEFECTIVE INTRACELLULAR ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-03-16 | — | — | WO | claimed |
| US-20060052448-A1 | Use of methyl pyruvate or methyl pyruvic acid for the treatment of diseases of the nervous system and for protecting a human central nervous system against neuronal degeneration caused by defective intracellular energy production. | Antosh, Mr. Stanley (US) | 2006-03-09 | — | — | US | claimed |
| WO-2006017590-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2006-02-16 | — | — | WO | claimed |
| WO-2006015232-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-02-09 | — | — | WO | claimed |
| US-20060025475-A1 | Use of methyl pyruvate for the purpose of increasing muscle energy production. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | claimed |
| US-20060025476-A1 | Use of methyl pyruvate for the purpose of reducing weight gain in mammals. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | claimed |
| EP-1781108-A4 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2006017590-A3 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2007-08-16 | — | — | WO | disclosed |
| EP-1781108-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006017590-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006015232-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025475-A1 | Use of methyl pyruvate for the purpose of increasing muscle energy production. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | disclosed |
| US-20060025476-A1 | Use of methyl pyruvate for the purpose of reducing weight gain in mammals. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | disclosed |