Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013328 | 0.87 | GABRA1 (0.59) | HTR2AGABRA1GABRB2MTNR1AMTNR1B | |
| SCHEMBL29066447 | 0.84 | HTR2A (0.46) | HTR2AGABRA1GABRB2MTNR1AMTNR1B | |
| SCHEMBL4630564 | 0.83 | ABCB11 (0.46) | GABRA1GABRB2MAPTLMNA | |
| SCHEMBL3458869 | 0.82 | HTR2A (0.47) | HTR2AGAA | |
| SCHEMBL3459047 | 0.82 | HTR2A (0.70) | HTR2AGABRA1GABRB2GAA | |
| SCHEMBL13692380 | 0.82 | HTR2A (0.70) | HTR2AGABRA1GABRB2GAA | |
| SCHEMBL3458865 | 0.82 | HTR2A (0.47) | HTR2AGAA | |
| SCHEMBL17571961 | 0.81 | HTR2A (0.46) | HTR2AGAAALDH1A1 | |
| SCHEMBL4121937 | 0.80 | ERN1 (0.50) | HTR2AMTNR1AMTNR1BGAAKDM4E | |
| SCHEMBL8959159 | 0.79 | GAA (0.50) | MTNR1AMTNR1BGAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355889-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF COUGH | Afferent Pharmaceuticals Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3164132-A1 | METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS | Afferent Pharmaceuticals Inc. (US) | 2017-05-10 | — | — | EP | disclosed |
| EP-3035932-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X 2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE, SUB-ACUTE OR CHRONIC COUGH | Afferent Pharmaceuticals Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2016004358-A1 | METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS | Afferent Pharmaceuticals, Inc. (US) | 2016-01-07 | — | — | WO | disclosed |
| WO-2015027212-A1 | DIAMINOPYRIMIDINE P2X3 AND P2X 2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE, SUB-ACUTE OR CHRONIC COUGH | AFFERENT PHARMACEUTICALS INC. (US) | 2015-02-26 | — | — | WO | disclosed |
| EP-1926716-A1 | PROCESS FOR SYNTHESIS OF ARYLOXY DIAMINOPYRIMIDINES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-04 | — | — | EP | disclosed |
| EP-1924264-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025898-A1 | PROCESS FOR SYNTHESIS OF ARYLOXY DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025925-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| EP-1725540-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005095359-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-13 | — | — | WO | disclosed |