Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL9450682 | 0.89 | GNAI3 (0.32) | GNAI3GNAO1GNAI1 | |
| SCHEMBL34371 | 0.85 | — | — | |
| Ammonia Solution, Strong SCHEMBL28242181 | 0.83 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 | |
| SCHEMBL7527875 | 0.83 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 | |
| Urea SCHEMBL6942842 | 0.83 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 | |
| SCHEMBL27888790 | 0.83 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 | |
| SCHEMBL28189279 | 0.83 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 | |
| Nitrogen SCHEMBL20898038 | 0.81 | GNAI3 (0.33) | GNAI3GNAO1GNAI1 | |
| Propene SCHEMBL27563440 | 0.79 | GNAI3 (0.33) | GNAI3GNAO1GNAI1 | |
| Trolamine SCHEMBL9054341 | 0.78 | GNAI3 (0.31) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1734965-A4 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | ADVANCED VISION RES INC (US) | 2008-06-11 | — | — | EP | claimed |
| EP-1734965-A1 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | Advanced Vision Research, Inc. (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005097130-A1 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | ADVANCED VISION RESEARCH, INC. (US) | 2005-10-20 | — | — | WO | claimed |
| US-20050220742-A1 | Compositions and methods for maintaining eyelid hygiene | BREEN ED V | 2005-10-06 | — | — | US | claimed |
| US-20050137205-A1 | Formulation for treating periocular disease | DBD DESIGN INC. | 2005-06-23 | — | — | US | claimed |
| CN-102397169-B | Cosmetic with free radical scavenging function | UNIV HUNGKUANG | 2014-02-12 | — | — | CN | disclosed |
| CN-102397169-A | Cosmetic with free radical scavenging function | UNIV HUNGKUANG | 2012-04-04 | — | — | CN | disclosed |
| EP-1734965-A4 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | ADVANCED VISION RES INC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2008021873-A2 | STABILIZED LIQUID PRESERVATIVE COMPOSITIONS | ISP INVESTMENTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20070231353-A1 | Compositons and methods for maintaining eyelid hygiene | ADVANCED VISION RESEARCH, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| EP-1734965-A1 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | Advanced Vision Research, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097130-A1 | NEW COMPOSITIONS AND METHODS FOR MAINTAINING EYELID HYGIENE | ADVANCED VISION RESEARCH, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| US-20050220742-A1 | Compositions and methods for maintaining eyelid hygiene | BREEN ED V | 2005-10-06 | — | — | US | disclosed |