Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30430210 | 0.83 | KDM4E (0.50) | ALDH1A1KMT2AMEN1HPGDNPSR1 | |
| SCHEMBL4632412 | 0.83 | KDM4E (0.50) | ALDH1A1KMT2AMEN1HPGDNPSR1 | |
| SCHEMBL14302077 | 0.78 | HDAC1 (0.52) | ALDH1A1CYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL17342166 | 0.78 | HTT (0.54) | ALDH1A1CYP1A2KMT2AHTTUSP2 | |
| SCHEMBL28540549 | 0.78 | SMN1; SMN2 (0.54) | F10ALDH1A1CYP1A2CYP2C19KMT2A | |
| SCHEMBL16080074 | 0.77 | USP2 (0.40) | ALDH1A1CYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL22380 | 0.74 | ALDH1A1 (0.48) | ALDH1A1CYP1A2KMT2AMEN1MAPT | |
| SCHEMBL10213140 | 0.74 | KMT2A (0.40) | ALDH1A1CYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL28551538 | 0.74 | USP2 (0.40) | ALDH1A1CYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL29395460 | 0.74 | ALDH1A1 (0.48) | ALDH1A1CYP1A2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110719908-B | Process for preparing 3, 4-dichloro-N- (2-cyanophenyl) -5-isothiazolecarboxamide | 拜耳股份公司 | 2023-05-26 | — | — | CN | disclosed |
| US-11220487-B2 | Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide | BAYER AKTIENGESELLSCHAFT (DE) | 2022-01-11 | — | — | US | disclosed |
| US-11220487-B2 | Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide | BAYER AKTIENGESELLSCHAFT (DE) | 2022-01-11 | — | — | US | disclosed |
| EP-3638653-B1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER AG (DE) | 2021-12-15 | — | — | EP | disclosed |
| EP-3638653-B1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER AG (DE) | 2021-12-15 | — | — | EP | disclosed |
| US-20200140401-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2020-05-07 | — | — | US | disclosed |
| US-20200140401-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2020-05-07 | — | — | US | disclosed |
| EP-3638653-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | Bayer Aktiengesellschaft (DE) | 2020-04-22 | — | — | EP | disclosed |
| CN-110719908-A | Process for the preparation of 3, 4-dichloro-N- (2-cyanophenyl) -5-isothiazolecarboxamide | 拜耳股份公司 | 2020-01-21 | — | — | CN | disclosed |
| WO-2018228984-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2018-12-20 | — | — | WO | disclosed |
| EP-2573077-B1 | METHOD FOR PRODUCING 3,4-DICHLOR-N-(2-CYANO-PHENYL)-5-ISOTHIAZOLE CARBOXAMIDE | BAYER CROPSCIENCE AG (DE) | 2017-10-04 | — | — | EP | disclosed |
| EP-2573077-B1 | METHOD FOR PRODUCING 3,4-DICHLOR-N-(2-CYANO-PHENYL)-5-ISOTHIAZOLE CARBOXAMIDE | BAYER CROPSCIENCE AG (DE) | 2017-10-04 | — | — | EP | disclosed |
| EP-2573077-A1 | Method for producing 3,4-dichlor-N-(2-cyano-phenyl)-5-isothiazole carboxamide | Bayer CropScience AG (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-2573077-A1 | Method for producing 3,4-dichlor-N-(2-cyano-phenyl)-5-isothiazole carboxamide | Bayer CropScience AG (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-1926717-B1 | Process for preparing 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazole-carboxamide | BAYER CROPSCIENCE AG (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-1926717-B1 | Process for preparing 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazole-carboxamide | BAYER CROPSCIENCE AG (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-1926717-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | Bayer CropScience Aktiengesellschaft (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031146-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031146-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220487-B2 | Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide | SPECC1L, CCNL2, MCM4 | F10 1983/4885ALDH1A1 2161/4885CYP1A2 2162/4885 |
| US-20200140401-A1 | PROCESS FOR PREPARING 3,4-DICHLORO-N-(2-CYANOPHENYL)-5-ISOTHIAZOLECARBOXAMIDE | SPECC1L, CCNL2, MCM4 | F10 1983/4885ALDH1A1 2161/4885CYP1A2 2162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.