Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632998 | 0.94 | KDM4E (0.35) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL4633218 | 0.88 | KDM4E (0.33) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL4634190 | 0.83 | SLC22A12 (0.34) | ALDH1A1GAAHPGDHSD17B10CYP1A2 | |
| SCHEMBL4632933 | 0.78 | SMN1; SMN2 (0.37) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL5901177 | 0.78 | KDM4E (0.30) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL3555267 | 0.72 | ALDH1A1 (0.34) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL5901876 | 0.72 | CYP3A4 (0.39) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL4592754 | 0.72 | CYP3A4 (0.61) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL4777017 | 0.71 | NPC1 (0.34) | KDM4EALDH1A1GAAPABPC1HPGD | |
| SCHEMBL4592596 | 0.71 | MAP4K1 (0.36) | KDM4EALDH1A1GAAPABPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | claimed |
| WO-2007023135-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2007-03-01 | — | — | WO | claimed |
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007023135-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2007-03-01 | — | — | WO | disclosed |