Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125381 | 0.90 | BCL2 (0.49) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4125379 | 0.90 | BCL2 (0.49) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4277628 | 0.89 | BCL2 (0.48) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4277634 | 0.89 | BCL2 (0.48) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4124023 | 0.83 | ALOX5 (0.48) | EGFRERBB2ALOX5MEN1KMT2A | |
| SCHEMBL4120978 | 0.83 | EGFR (0.48) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4794860 | 0.83 | ALOX5 (0.48) | EGFRERBB2ALOX5MEN1KMT2A | |
| SCHEMBL4120979 | 0.83 | EGFR (0.48) | EGFRERBB2PTGESALOX5RORC | |
| SCHEMBL4124192 | 0.82 | RORC (0.38) | EGFRERBB2RORCBCL2L1MCL1 | |
| SCHEMBL4137534 | 0.82 | ALOX5 (0.52) | EGFRERBB2ALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | claimed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | claimed |