Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CETP | P11597 | 3/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669129 | 0.87 | TSHR (0.55) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL17359392 | 0.81 | TSHR (0.49) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL17357042 | 0.79 | TSHR (0.54) | TSHRALDH1A1CETPFOLH1MAPK1 | |
| SCHEMBL13892565 | 0.78 | TSHR (0.56) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL13228165 | 0.78 | TSHR (0.45) | TSHRCETPFOLH1TDP1MAPT | |
| SCHEMBL14139643 | 0.78 | TSHR (0.45) | TSHRCETPFOLH1LMNAKLK1 | |
| SCHEMBL13892549 | 0.77 | TSHR (0.55) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL23748497 | 0.76 | ALDH1A1 (0.50) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL11214279 | 0.76 | TSHR (0.50) | TSHRALDH1A1CETPFOLH1NPC1 | |
| SCHEMBL10832425 | 0.75 | TSHR (0.62) | TSHRALDH1A1CETPFOLH1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928890-A2 | PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007096703-A2 | PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-08-30 | — | — | WO | disclosed |