Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 5/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27967465 | 0.89 | CYP46A1 (0.48) | CYP46A1AVPR1ASSTR5HSD11B1OPRM1 | |
| SCHEMBL3833018 | 0.85 | AVPR1A (0.62) | CYP46A1AVPR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL23365166 | 0.84 | CYP46A1 (0.45) | CYP46A1AVPR1ASSTR5OPRM1OPRD1 | |
| SCHEMBL5993589 | 0.84 | CYP46A1 (0.50) | CYP46A1AVPR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL15537084 | 0.84 | EPHX2 (0.53) | CYP46A1AVPR1AHSD11B1CYP3A4EPHX2 | |
| SCHEMBL3063019 | 0.84 | HSD11B1 (0.45) | CYP46A1AVPR1ASSTR5HSD11B1CYP3A4 | |
| SCHEMBL23365209 | 0.84 | GRIN2B (0.45) | CYP46A1AVPR1AOPRM1OPRD1OPRK1 | |
| SCHEMBL23365119 | 0.82 | CYP46A1 (0.52) | CYP46A1AVPR1AOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5810883 | 0.82 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL5234910 | 0.81 | OPRD1 (0.50) | AVPR1ASSTR5OPRM1OPRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2006086609-A2 | INHIBITORS OF TRYPTASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |