Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122732 | 1.00 | PTGS1 (0.38) | PTGS1PTGS2AKR1C3AKR1C2MAPT | |
| SCHEMBL4634551 | 0.80 | PTGS1 (0.37) | PTGS1PTGS2AKR1C3AKR1C2MAPT | |
| SCHEMBL4134174 | 0.73 | AKR1C3 (0.36) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL4134176 | 0.73 | AKR1C3 (0.36) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL16216330 | 0.70 | AKR1C3 (0.52) | PTGS1PTGS2AKR1C3AKR1C2MAPT | |
| SCHEMBL16207559 | 0.70 | AKR1C3 (0.52) | PTGS1PTGS2AKR1C3AKR1C2MAPT | |
| SCHEMBL10914645 | 0.63 | AKR1C3 (0.52) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL10777346 | 0.61 | GAA (0.45) | AKR1C3AKR1C2MAPTMEN1KMT2A | |
| SCHEMBL11588632 | 0.60 | PTGS2 (0.50) | PTGS1PTGS2MEN1KMT2ALMNA | |
| SCHEMBL3584977 | 0.59 | ALDH1A1 (0.50) | AKR1C3AKR1C2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | claimed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | claimed |