Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | CHAT | P28329 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4634200 | 1.00 | KMT2A (0.40) | KMT2AMEN1CHATNR1H3ALDH1A1 | |
| SCHEMBL4633403 | 0.99 | KMT2A (0.41) | KMT2AMEN1CHATNR1H3ALDH1A1 | |
| SCHEMBL4634206 | 0.99 | KMT2A (0.41) | KMT2AMEN1CHATNR1H3ALDH1A1 | |
| Bromide SCHEMBL4535340 | 0.85 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTHTT | |
| Bromide SCHEMBL4535352 | 0.85 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTHTT | |
| Bromide SCHEMBL4534732 | 0.82 | MEN1 (0.41) | KMT2AMEN1CHATALDH1A1MAPT | |
| Bromide SCHEMBL4532718 | 0.82 | MEN1 (0.41) | KMT2AMEN1CHATALDH1A1MAPT | |
| Bromide SCHEMBL3890946 | 0.76 | MEN1 (0.39) | KMT2AMEN1CHATALDH1A1MAPT | |
| Bromide SCHEMBL3890949 | 0.76 | MEN1 (0.39) | KMT2AMEN1CHATALDH1A1MAPT | |
| SCHEMBL5711637 | 0.75 | MEN1 (0.40) | KMT2AMEN1CHATALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729723-B1 | NEUTRAL AND CATIONIC NAPHTHALENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS FOR DYEING KERATIN FIBERS | WELLA AG (DE) | 2008-06-04 | — | — | EP | claimed |
| US-20070151046-A1 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | Wella GmbH (DE) | 2007-07-05 | — | — | US | claimed |
| EP-1729723-A1 | NEUTRAL AND CATIONIC NAPHTHALENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS FOR DYEING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005075574-A1 | NEUTRAL AND CATIONIC NAPHTHALENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS FOR DYEING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070151046-A1 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | KRT18, NUP205, KPNA1 | KMT2A 2261/4885MEN1 2181/4885CHAT 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.