SCHEMBL4635160

SCHEMBL4635160

CCC(C)NC(=O)C1CCNC1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACACB O00763 2/20 0.52
GAA P10253 3/20 0.50
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
EPHX1 P07099 1/20 0.41
CHRNB2 P17787 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA7 P36544 1/20 0.39
CHRNA4 P43681 1/20 0.39
BRPF1 P55201 1/20 0.39
GNAI3 P08754 1/20 0.39
GNAO1 P09471 1/20 0.39
GNAI1 P63096 1/20 0.39
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13746392 0.90 GAA (0.56) ACACBGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL4634787 0.85 ACACB (0.44) ACACBGAASMN1; SMN2CHRNB2CHRNB4
SCHEMBL12696525 0.82 CHRNB2 (0.56) ACACBKDM4ESMN1; SMN2CHRNB2CHRNB4
SCHEMBL16036865 0.82 CHRNB2 (0.56) ACACBKDM4ESMN1; SMN2CHRNB2CHRNB4
Hydrochloric Acid SCHEMBL2146410 0.81 CHRNB2 (0.54) ACACBKDM4ESMN1; SMN2CHRNB2CHRNB4
Hydrochloric Acid SCHEMBL2146404 0.81 CHRNB2 (0.54) ACACBKDM4ESMN1; SMN2CHRNB2CHRNB4
SCHEMBL23480154 0.80 GAA (0.65) ACACBGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL14241975 0.80 GAA (0.65) ACACBGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL24063090 0.80 ACACB (0.41) ACACBGAAKDM4ECHRNB2CHRNB4
SCHEMBL12574191 0.77 GNAI3 (0.51) ACACBALDH1A1KDM4ESMN1; SMN2CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1638933-B1 N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS PFIZER LTD (GB) 2008-06-11 EP claimed